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Evidence-based decision support for integrating genetic testing into everyday clinical practice. Know when to test, what to order, and how to act on results.
Explore Clinical PathwaysGenetic testing has moved from research curiosity to clinical necessity. The evidence, accessibility, and diagnostic power are here. The question is no longer whether to integrate genomics, but how quickly.
Across 20 organ systems, exome and genome sequencing delivers a molecular diagnosis in roughly half of appropriately selected patients, far exceeding most imaging and laboratory workups.
The average rare disease patient sees 7+ specialists over 5 to 7 years before receiving a diagnosis. A single genetic test can collapse that timeline to weeks.
In pediatric and cardiac ICU settings, 80% of positive genomic diagnoses directly change the clinical management plan, from medication adjustments to surgical decisions.
Clinical-grade exome sequencing now starts at $250 to $3,000, making definitive molecular diagnosis cost-competitive with a single MRI or specialist consultation.
Structured workflows for determining when genetic testing is indicated, selecting the right test, and interpreting results within the clinical context of each specialty.
Guideline-based testing pathways for heritable cardiomyopathies, arrhythmia syndromes, aortopathies, and familial hypercholesterolemia. Cascade screening algorithms for at-risk family members.
Testing algorithms for unexplained epilepsy, hereditary neuropathies, movement disorders, and leukodystrophies. Rapid sequencing pathways for neonatal-onset neurological presentations.
Germline and somatic testing workflows for hereditary cancer syndromes, tumor profiling for therapy selection, and pharmacogenomic guidance for chemotherapy dosing and adverse event prevention.
Diagnostic algorithms for steroid-resistant nephrotic syndrome, unexplained CKD in young adults, CAKUT, cystic kidney diseases, and genetic tubulopathies. Early diagnosis enables targeted management and transplant planning.
Rapid genome sequencing protocols for critically ill neonates and children with multiple congenital anomalies or unexplained developmental delay. Median turnaround of 3 to 7 days with documented reductions in length of stay.
Practical tools and resources designed for clinicians who need to make genomic decisions at the point of care, not in a research lab.
Indication-specific algorithms that guide you from clinical suspicion to the right genetic test, with clear criteria for when sequencing adds value over traditional workup.
Step-by-step workflows for test selection across 20 organ systems, including when to choose panels, exome, or genome sequencing, and how to handle variants of uncertain significance.
Plain-language frameworks for reading genetic test reports, understanding pathogenicity classifications, and translating molecular findings into actionable clinical decisions.
Continuing medical education modules covering genomic fundamentals, specialty-specific applications, and emerging evidence, designed for physicians at any level of genetic literacy.